International Research Scholars Program

Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription

CC Bell, JJ Balic, L Talarmain, A Gillespie, L Scolamiero, EYN Lam, CS Ang, GJ Faulkner, O Gilan, MA Dawson

2024-06-01

Eukaryotic transcription factors (TFs) activate gene expression by recruiting cofactors to promoters. However, the relationships b..

Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity

AA Guirguis, Y Ofir-Rosenfeld, K Knezevic, W Blackaby, D Hardick, YC Chan, A Motazedian, A Gillespie, D Vassiliadis, EYN Lam, K Tran, B Andrews, ME Harbour, L Vasiliauskaite, CJ Saunders, G Tsagkogeorga, A Azevedo, J Obacz, ES Pilka, M Carkill

2023-10-01

Therapies that enhance antitumor immunity have altered the natural history of many cancers. Consequently, leveraging nonoverlappin..

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

KL Chan, J Gomez, C Cardinez, N Kumari, CE Sparbier, EYN Lam, MM Yeung, S Garciaz, JA Kuzich, DM Ong, FC Brown, YC Chan, D Vassiliadis, EN Wainwright, A Motazedian, A Gillespie, KA Fennell, J Lai, IG House, L Macpherson

2022-10-10

There is increasing recognition of the prognostic significance of tumor cell major histocompatibility complex (MHC) class II expre..

Detection of cell-free microbial DNA using a contaminant-controlled analysis framework

E Zozaya-Valdés, SQ Wong, J Raleigh, A Hatzimihalis, S Ftouni, AT Papenfuss, S Sandhu, MA Dawson, SJ Dawson

2021-12-01

Background: The human microbiome plays an important role in cancer. Accumulating evidence indicates that commensal microbiome-deri..

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

CC Bell, KA Fennell, YC Chan, F Rambow, MM Yeung, D Vassiliadis, L Lara, P Yeh, LG Martelotto, A Rogiers, BE Kremer, O Barbash, HP Mohammad, TM Johanson, ML Burr, A Dhar, N Karpinich, L Tian, DS Tyler, L MacPherson

2019-12-01

Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it..

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

ML Burr, CE Sparbier, KL Chan, YC Chan, A Kersbergen, EYN Lam, E Azidis-Yates, D Vassiliadis, CC Bell, O Gilan, S Jackson, L Tan, SQ Wong, S Hollizeck, EM Michalak, HV Siddle, MT McCabe, RK Prinjha, GR Guerra, BJ Solomon

2019-10-14

Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 sc..

Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

R Agarwal, YC Chan, CS Tam, T Hunter, D Vassiliadis, CE Teh, R Thijssen, P Yeh, SQ Wong, S Ftouni, EYN Lam, MA Anderson, C Pott, O Gilan, CC Bell, K Knezevic, P Blombery, K Rayeroux, A Zordan, J Li

2019-01-01

Ibrutinib plus venetoclax is a highly effective combination in mantle cell lymphoma. However, strategies to enable the evaluation ..